Among the first to explore NK
adoptive immunotherapy were the groups at Frankfurt University and Basel University Hospital, focusing on pediatric and young adult patients.
Adoptive immunotherapy using CARs T-cells is emerging as a novel approach to pancreatic cancer immunotherapy.
Schuessler et al., "Pre-emptive and therapeutic
adoptive immunotherapy for nasopharyngeal carcinoma: Phenotype and effector function of T cells impact on clinical response," OncoImmunology, vol.
Earlier studies on
adoptive immunotherapy have been summarised in recent reviews [47, 55-58].
Genetic engineering of T cells for
adoptive immunotherapy. Immunol Res, 2008, 42, 166-181.
The principle behind the company's business is based on the emerging field of
adoptive immunotherapy, or biological therapy, which has been successfully used around the world to treat a wide variety of cancers and chronic viral infections.
"We view T-cell
adoptive immunotherapy as particularly appealing for patients whose tumor burdens might be too large or too aggressive to warrant administration with cancer vaccines."
A major difficulty in
adoptive immunotherapy has been identifying those lymphocytes among all those present in the body that are most active against a tumor.
Rosenberg calls his treatment with the special lymphocytes "
adoptive immunotherapy." This therapy has produced some remarkable effects including the complete disappearance of cancer in patients who are near death.