Total GX and resection of the acid-producing part of the stomach (fundectomy) induces gastrinemia and malnutrition [13,14], thereby initiating osteopenia in rats [15-19].
Therefore, it is logical that any agent that impairs calcium absorption could result in hypocalcemia.Animal studies have demonstrated 100% mortality due to hypocalcemia in rats that are rendered hypoparathyroid and then undergo gastrectomy and fundectomy. In contrast, no mortality was observed in rats with parathyroidectomy alone.