active site

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active site

The part of an enzyme at which catalysis of the substrate occurs.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

ac·tive site

(ăk′tĭv)

The part of an enzyme where the substance that the enzyme acts upon (called the substrate) is catalyzed. See more at enzyme.

The American Heritage® Student Science Dictionary, Second Edition. Copyright © 2014 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

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Noun

active site - the part of an enzyme or antibody where the chemical reaction occurs

site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"

enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

antibody - any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response

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MECHANISM OF ACTION OF NEWER ANTICOAGULANTS: Thrombin-inhibiting drugs can block the action of thrombin by binding to three domains: the active site or catalytic site and two exosites.

Pharmacological aspects of newer drugs used in anticoagulant therapy

* The DNA polymerase binds to the primer/template pair with the enzyme active site placed over the 3'-01-1 of the printer.

DNA replication: polymerases

Figure 4 shows a typical hydrogen bubble growth period on an active site of photocatalyst.

In situ measurement of local hydrogen production rate by bubble-evolved recording

[Ni.sup.2+] ions and the sulfhydryl group, especially the multiple cysteinyl residues in the active site of the enzyme, are essential for the catalytic activity of all ureases.

Kinetics and mechanism study of competitive inhibition of Jack-Bean urease by Baicalin

University of Birmingham experts found there was a negative effect on the prices of homes within 1.8 miles (3km) of an active site, and within 0.6 miles (1km) of an inactive site.

Landfill sites 'hit value of houses'

of Warwick, England) explains that for this edition he has enhanced the interplay of enzyme active site structure with their catalytic mechanisms, added findings and research topics from the recent literature, and redrawn the figures of protein structures with a program--PyMOL--he hopes will improve the resolution.

Introduction to enzyme and coenzyme chemistry, 3d ed

Just as immunization with a killed virus induces the immune system to create antibodies that then attack live viruses, an MMP immunization would trick the body into creating antibodies that block the enzyme at its active site.

New Synthetic Molecules Treat Autoimmune Disease in Mice

In order to block the action of an enzyme, it's usually necessary to create a molecule that binds to its active site. But a group of researchers at the University of Toronto Mississauga (UTM) have come up with a different strategy--they simply throw out an anchor.

Protein-membrane anchors offer new cancer strategy: protein-membrane anchors have two domains; a 'key' domain which binds to some part of the target molecule, and an 'anchor' domain which is attracted to the non-polar cell membrane. A team from the University of Toronto Mississauga is using this strategy to block the STAT3 signalling pathway, which is implicated in certain cancers

Figure 6 also shows the MWD of the polymer produced by each deconvoluted active site. It can be observed that the MWD deconvolution requires the definition of at least three distinct active sites, which is an indirect confirmation of the existence of many distinct catalyst sites in the reaction environment.

Analysis of solution polybutadiene polymerizations performed with a neodymium catalyst

Antiviral drugs can wedge into a cavity within an active site of the N1 enzyme (shown), stopping the enzyme's action and blocking the release of new viral particles.

Better flu-fighting models

The team constructed a computational model of the enzyme's active site and used density functional theory calculations to simulate the demethylation reaction.

Methylmercury breakdown

For example, the invention provides a method for identifying a thermostable polymerase having altered fidelity by mutating at least one amino acid residue in an active site O-helix of a thermostable polymerase.