According to the company, the proceeds will be used to accelerate the development of its pipeline, to expand its mutation,
allostery and pharmacology computational and discovery platform for identifying and targeting allosteric oncogenic mutations, to establish its new corporate headquarters in Cambridge, MA, advance two-to-three existing development candidates into the clinic as well as to bolster its platform's ability to identify precision medicines for mutant cancers intractable to standard care.
During its stealth stage, Black Diamond built and established proof of concept for its MAP (mutation,
allostery and pharmacology) platform to uncover, discover and target allosteric mutant oncogenes.
The structure of bovine glutamate dehydrogenase provides insights into the mechanism of
allostery. Structure 1999;7:769-82.
The differential pleiotrophy of mutations in TF loci has been attributed to an ensemble nature to
allostery of intrinsically disordered proteins [49], but alternatively differential pleiotrophy may also be an expected outcome in the model of limited specificity.
[78] applied molecular dynamics simulations and structural analyses to elucidate mechanisms of mutation-induced
allostery in CYP1A2.
Indeed,
allostery has remained as a key theory in biology and biochemistry since the quantitative explanation this theory allows regarding the biological activity of oligomeric proteins is fundamental for understanding a variety of cellular processes such as hormone action, gene repression and enzyme kinetics, among others.
(2013) Modulation of
allostery by protein intrinsic disorder.
Monrovia, CA, August 27, 2016 --(PR.com)-- Terry Hebert, Professor of Pharmacology and Therapeuticsat at McGill University, will give a presentation on, "Assessing Bias and
Allostery in GPCRs using Conformational Biosensors" at GTCbio's 4th GPCR in Drug Discovery Conference to be held on September 14-15, 2016 in Boston, MA.
Specific topics include from classical thermo-chemistry to monitoring living organisms, thermotropic properties of ceramides in aqueous or lipidic environments,
allostery and cooperative interactions in proteins assessed by isothermal titration calorimetry, protein stability in crowded environments, and calorimetry to monitoring mixed bacterial populations and biofilms.