aTyr's research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality of tRNA
synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA
synthetase genes.
BT-11 is a first-in-class, oral, gut-restricted small molecule therapeutic with a unique mechanism of action that targets a novel pathway called Lanthionine
Synthetase C-Like 2 (LANCL2).
"We continue to execute our clinical development plan for our lead therapeutic candidate, ATYR1923, while also entering into meaningful collaborations with both academic institutions and global drug development partners that leverage our novel tRNA
synthetase biology," said Sanjay Shukla, president and CEO of aTyr.
Anti-KS: identification of autoantibodies to asparaginyl-transfer RNA
synthetase associated with interstitial lung disease.
The anticodon is relatively distant from the
synthetase binding site, but scientists since the early 1990s have speculated that tRNAs were once much smaller, combining the anticodon and
synthetase binding regions in one.
Topics include reconstruction of glutamine
synthetase using computer averaging, a cryo-electron microscopic study of ribosome-bound termination factor RF2, the process of mRNA-tRNA translocation, and the structural basis for gating and activation of RyR1.
Glutathione
synthetase deficiency (GSSD) is a rare inborn error of glutathione metabolism with an autosomal recessive inheritance, which is caused by mutations in the GSS gene (OMIM 601002) (1).
This antibody was classified as myositis-specific autoantibody and its corresponding antigen was reported to be a 50-kDa histidine transfer ribonucleic acid (tRNA)
synthetase, a type of cytoplasmic aminoacyl-tRNA
synthetase (ARS).
Further, metastasis was found greatly limited by reducing asparagine
synthetase, treatment with the chemotherapy drug L-asparaginase, or dietary restriction.
, the team discovered that the appearance of asparagine
synthetase -- the enzyme cells used to make asparagine -- in a primary tumour was strongly associated with later cancer spread.
Anti-aminoacyl-tRNA
synthetase syndromes (ARS) comprise a subset of patients with idiopathic inflammatory myopathy (IIM), predominantly, polymyositis (PM) and dermatomyositis (DM), and overlap myositis syndromes.
Mutations and polymorphisms in the human argininosuccinate
synthetase (ASS1) gene.