The effect of ormeloxifene, a
selective estrogen receptor modulator, on the biomarkers of the endometrial receptivity and the pinopode development and its relationship with the fertility and the infertility in Indian subjects.
(19,20) However, because estrogen administration can increase the risk of breast and uterine cancer, researchers are instead investigating
selective estrogen receptor modulators (SERMs).
Jordan, "The discovery and development of
selective estrogen receptor modulators (SERMs) for clinical practice," Current Clinical Pharmacology, vol.
Selective estrogen receptor modulators (SERMS) are estrogen receptor ligands that exert estrogen agonistic or antagonistic activity in a tissue-specific manner.
Effects of two novel
selective estrogen receptor modulators, raloxifene, tamoxifen, and ethinyl estradiol on the uterus, vagina and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis).
The
selective estrogen receptor modulator raloxifene regulates osteoclast and osteoblast activity in vitro.
Raloxifene (Evista[R]): An estrogen agonist/antagonist (or
selective estrogen receptor modulator) approved by the FDA for prevention and treatment of osteoporosis.
Raloxifene is a
selective estrogen receptor modulator, specifically developed to maintain beneficial estrogenic activity on bone and lipids and antiestrogenic activity on endometrial and breast tissue.
Today, several medications are available for the prevention or treatment of osteoporosis, such as Evista (raloxifene), a
selective estrogen receptor modulator, or SERM, which is protective against vertebral fractures.
AFI: Evista (raloxifene) is a
selective estrogen receptor modulator (SERM) (See AFI, February 2000 for a detailed review of the drug).
Ligand Pharmaceuticals Incorporated (Nasdaq: LGND) has earned an undisclosed milestone payment from Wyeth-Ayerst Laboratories, the pharmaceutical division of American Home Products Corporation (NYSE: AHP), as a result of Wyeth's initiation of Phase III clinical trials for TSE-424, a
selective estrogen receptor modulator (SERM), in osteoporosis and hormone replacement therapy (HRT).