United Kingdom-based AstraZeneca and United States-based MSD have revealed positive results from the Phase III PROfound trial of Lynparza (olaparib) in men with metastatic castration-resistant prostate cancer who have a homologous recombination repair
gene mutation and have progressed on prior treatment with new hormonal anticancer treatments, it was reported yesterday.
AstraZeneca (AZN) and Merck (MRK) announced results from the Phase 3 PROfound trial of Lynparza in men with metastatic castration-resistant prostate cancer - mCRPC - who have an homologous recombination repair
gene mutation and have progressed on prior treatment with new hormonal anticancer treatments.
The medicine is for those newly-diagnosed with ovarian cancer that has spread, who have the BRCA
gene mutation. Inherited BRCA
gene mutations are responsible for about one in five ovarian cancers.
In 1996, two
gene mutation of HFE were found to be responsible for hemochromatosis i.e.
Most cancers develop after a
gene mutation happens during a person's lifetime, in an organ where a cancer later develops.
The same SETX
gene mutation, c.5268delT (p.Phe1756LeufsX30), in heterozygous status was detected in the second case (figure 2).
During her degree she lost her mum to ovarian cancer and later discovered it was the result of her carrying a harmful BRCA2
gene mutation.
The origin of the Linear-No-Threshold (LNT) belief was borne in the judgment and passion of Hermann Muller, who was the first to claim that X-rays induced
gene mutations. Muller had indeed made a momentous breakthrough in late 1926 when he found a way to produce quickly copious transgenerational phenotypic changes (e.g., alterations in size, color, or shape) in fruit flies, which he interpreted as being the result of
gene mutation.
The team also found that in a subset of triple negative breast cancer cells associated with the BRCA1
gene mutation, LYN could be switched on and increase cancer cell survival directly as a result of the loss of BRCA1.
I was part of a team at Oregon Health & Science University that used CRISPR gene editing to correct a disease-causing
gene mutation in human embryos.
[USA], Oct 10 (ANI): Turns out, people with the natural
gene mutation appear to have an advantage when it comes to diet.