antipyresis

The dose of aspirinwas observed to identify the interactions involving this drug, since, for specific interactions involving acetylsalicylic acid, Drug-Reax[R] software informs, in the clinical management section, whether it occurs with doses used for analgesia and antipyresis (> 300 mg) or platelet antiaggregant effect (70-300 mg) (7).

Paracetamol produces analgesia and antipyresis by a mechanism similar to that of salicylate, which involves inhibition of prostaglandin synthesis.

1), which is a major phenolic active component extracted from the root cortex of the Paeonia suffruticosa, possesses extensive pharmacological activities such as sedation, antipyresis, anticoagulation (Fu et al., 2012), anti-oxidation (Bao et al., 2013), anti-inflammation (Himaya et al., 2012), and immunoregulation (Peng et al., 2013).

The Chinese herb Paeonia suffruticosa has been shown to possess therapeutic effects such as sedation, hypnosis, antipyresis, analgesic, anti-inflammation, and immunoregulation [39].

The plasma concentrations of paracetamol required to produce antipyresis and analgesia are still uncertain.

Integrated pharmacokinetic-pharmacodynamic model for acetaminophen, ibuprofen, and placebo antipyresis in children.

However, it is recommended to use the lowest therapeutic dose that provides sufficient antipyresis to prevent adverse effects or toxicity related to the medication (American Academy of Pediatrics [AAP], 2001; Carson, 2003).