Agonism

Madrigal recognized that greater selectivity for thyroid hormone receptor (THR)- and liver targeting might overcome these challenges and deliver the full therapeutic potential of THR- agonism. Madrigal believes that resmetirom is the first orally administered, small-molecule, liver- directed, truly -selective THR agonist.

Serotonin syndrome results when this regulatory system is disrupted due to hyperstimulation of the postsynaptic serotonin receptors, mainly via agonism of the 5-HT2A and 5-HT1A receptors.

Then she surveys contemporary political dramaturgies from the perspectives of political logics, irony and interpellation, autonomy and affect, empathy and agonism, and antagonism and agency.

You can set filters on each half of the graph to limit results to a specific type (agonism or antagonism) by selecting an option from the pull-down menu below.

Despite many years of effort, this list still generates controversy, for instance about whether a chemical that is a positive reference for agonism can automatically serve as a positive control for binding assays (binding is a requisite precursor to agonism) or whether effects observed at relatively high concentrations or in specific cell/tissue types are broadly relevant.

Among our choices were two literal works of different genres - Gerald Graff's, Disliking Books at an early age and Deborah Tannen's article, The Chronicles of Higher Education - Agonism in the academy.

"In theory we should have some really simple ways to prevent PTSD from occurring if we get in there soon enough: reducing noradrenergic overactivity via [alpha.sub.2]-adrenergic receptor agonism with an agent such as Clonidine; postsynaptic beta-adrenergic blocking with a drug such as propranolol; or [alpha.sub.1]-adrenergic receptor blocking, as with prazosin.

"In theory we should have some really simple ways to prevent PTSD from occurring if we get in there soon enough: reducing noradrenergic overactivity via alph[a.sub.2]-adrenergic receptor agonism with an agent such as Clonidine; postsynaptic beta-adrenergic blocking with a drug such as propranolol; or alph[a.sub.1]-adrenergic receptor blocking, as with prazosin.

The properties which made these drugs better than the typical ones were 5-HT2a antagonism, fast dissociation from D2 receptors and 5-HT1a agonism. Second generation antipsychotics were effective towards negative symptoms with lower risks of side effects (Lind et al., 2005).

The biopsies of responding patients demonstrated an increase in CD8+ T-effector cells and granzyme B expression and a reduction in CD4+ T-regulatory cells and FoxP3 expression, hallmarks of immune activation and anti-tumor activity associated with GITR agonism.

Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.

agonism and the associated side effects that are thought to be related to S-pioglitazone.