* Oncolytic
virotherapy is an emerging therapeutic option for cancer treatment.
In addition to his role as center director and professor of the Biodesign Center for Immunotherapy, Vaccines and
Virotherapy at ASU, Dr.
Oncolytic
virotherapy as an immunotherapeutic strategy for multiple myeloma.
The first genetically unmodified oncolytic
virotherapy,
"This study has clearly confirmed that oncolytic
virotherapy is able to create an inflamed phenotype and sensitize the tumor to immune checkpoint blockade," said Dr.
It's very significant because it shows, contrary to recent scientific claims, that
virotherapy can be combined with cell therapy for a positive effect," said the study's corresponding author Balveen Kaur, Ph.D., professor and vice chair of research in the Vivian L.
Previous scientific wisdom discredited combining
virotherapy and externally added NK cell therapy to the body's natural killer (NK) cells, but there could be clear cancer-fighting benefits - providing enough external NK cells are deployed to destroy the tumor and stop its spread, as revealed in this paper.
In the present paper, we report about our experience gained with PIPAC since July 2016 at a tertiary cancer center offering all other therapeutic options for peritoneal metastasis, including in particular palliative systemic chemotherapy, intraperitoneal chemotherapy, intraperitoneal
virotherapy [28], cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy (HIPEC).
Neutralizing antibodies are highly prevalent and can reduce the efficacy of repeat injections although how antivector immunity influences the clinical or biologic response of intratumoral
virotherapy is not known.