ERK inhibitors have been found to
resensitize BRAF mutant cancer cells that have acquired resistance to either BRAF or MEK inhibitors [142].
Additionally, another CDK4/6 inhibitor, abemaciclib, showed significant activity in HER2+ preclinical models, supporting the hypothesis that CDK4/6 inhibitors may
resensitize resistant tumors to the HER2 blockade [78].
Very recently, two research groups have reported independently that augmentation of miR-34a expression could
resensitize CCa cells to 5-fluorouracil-based chemotherapy [18, 19], pointing to an essential involvement of this important tumor suppressor miRNA in the metabolism of chemotherapeutic agents.
It had been proposed that a curcumin-induced reduction in stemness could
resensitize PDAC cell cultures to the commonly prescribed-but often resisted-Gemcitabine chemotherapy regimen.
In vitro experiments on neuronal cell lines under prolonged hyperinsulinemic conditions have shown that treatment with metformin was able to
resensitize insulin signalling and prevent the molecular and pathological changes observed in AD neurons [47].
M2 EQUITYBITES-August 5, 2016-AmpliPhi Biosciences receives Japanese Patent Office patent for phage therapy to
resensitize pseudomonas aeruginosa infections to antibiotics
Accordingly, two therapeutic strategies were currently used in the clinical trials: One was to inhibit the cytoprotective function of autophagy to improve the killing efficacy of chemotherapy drugs or
resensitize the chemoresistant tumor cells to drugs; the other was to induce autophagic cell death in the apoptosis-defective tumor cells, which showed high resistance to apoptosis by activating autophagic pathways.
This calls for the need to
resensitize medical missionaries and their organizational leaders to the possibility of severe mental health issues among their workers.
A combination of herbs known as adaptogens can be used effectively to
resensitize the hypothalamus and restore the adaptive homeostat.
(2011), would be to
resensitize cells to insulin by exposing resistant cells to drugs commonly applied in the treatment of IR [e.g., biguanides (metformin), thiazolidinediones (pioglitazone), nonsteroidal anti-inflammatory drugs].