Native LC3, or proLC3, is
proteolytically cleaved by autophagy-related4 (Atg4) releasing LC3-I, to which phosphatidylethanolamine is conjugated to generate the lipidated form of LC3 called LC3-II.
This may be due to the fact that albumin can be damaged during the antioxidant activity but can be rapidly renewed after being
proteolytically disrupt [21].
This holoenzyme is assembled from a barrel-shaped,
proteolytically active core particle and two 19S regulatory particles, capping both ends of the core particle cylinder.
This statement was proven by several scientific studies, in one of which, for example, it was demonstrated that furin-like proteinases
proteolytically activate the predominant form (p61) of Sema3E and promote tumor cell motility (10), whereas in other studies, the uncleavable form of Sema3E acts as anti-angiogenic and anti-metastatic factor (11, 12).
They may be
proteolytically lysed from the cell surface and released into the extracellular fluid to form serum soluble ICAM-1 (sICAM-1), soluble vascular intercellular adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE-selectin), etc.
Binding and substrate specificities of a Streptomyces olivaceoviridis chitinase in comparison with its
proteolytically processed form.
The CP includes three
proteolytically active subunits called [beta]1, [beta]2, and [beta]5 in the [beta]-ring and the active sites of these subunits are located inside the aforementioned cylindrical chamber.
However, direct application of routine targeted proteomics for the quantification of membrane proteins such as HER2 may encounter unique challenges, predominantly derived from their hydrophobic and
proteolytically resistant nature (37).
Other studies have shown that meprins
proteolytically process proteins involved in inflammation, an underlying process for renal fibrosis [27].
These
proteolytically truncated forms of RAGE and their high level in the serum of type 2 diabetes were also reported to induce the expression of inflammatory markers in other studies as well [26].
Yu, "Progranulin: a
proteolytically processed protein at the crossroads of inflammation and neurodegeneration," The Journal of Biological Chemistry, vol.
Myers et al., "Interleukin-6 signalling in juvenile idiopathic arthritis is limited by
proteolytically cleaved soluble interleukin-6 receptor," Rheumatology, vol.