Giannis, Development and biological evaluation of potent and specific inhibitors of mitotic
kinesin Eg5, Chem.
Five genes (ATPase phospholipid transporting 8A1 [ATP8A1 ], CCL1,
kinesin family member 20B, plasminogen, and PTPRC) were shown to be involved in the positive regulation of locomotion, and its network consisted of four GO terms (positive regulation of locomotion, positive regulation of cellular component movement, positive regulation of cell motility, and positive regulation of cell migration).
Literature reviews revealed pathogenic variants in the TUBBI (Tubulin Beta 1 Class VI), TUBBI (Tubulin Beta 2 Class II), TUBB3 (Tubulin Beta 3 Class III) (3), TUKLS (Tukel syndrome) (6), KIF21A (
Kinesin Family Member 21 A) (8), COL2A1 (Collagen Type XXV Alpha 1 Chain) (7) and PHOX2A (Paired Like Homeobox 2a) (2) genes in different types of CFEOM.
(12) In addition to EML4, less common fusion partners have been described, including TRK-fused gene (TFG),
kinesin light chain 1 (KLC1), and
kinesin family member 5B (KIF5B), although the clinical relevance of the different fusion partners is unknown.
Tyl and Friedman (28) elucidated this abnormality and stated that AA binds motor proteins
kinesin and dynein, thereby halting transaxonal transport and leading to distal axonopathy.
In addition, previous studies used cancer-specific immunotherapy based upon mitotic centromere-associated
kinesin (MCAK), a new cancer antigen (25).
In this way, it would destabilize microtubule assembly, cargo and samurai proteins dynamicity (such as dynein, cofactor dynactin,
kinesin, and samurai protein katanin), vesicle transport.
Bensel BM, Guzik-Lendrum S, Masucci EM, Woll KA, Eckenhoff RG, Gilbert SP.Common general anesthetic Propofol impairs
Kinesin processivity.
Interestingly, in pseudorabies virus (PRV; a porcine alphaherpesvirus), there does appear to be some virus-specificity in attachment of virions to dynein motor proteins (for axonal transport) versus
kinesin motor proteins (for axonal and/or dendritic transport) [164].
Beck, "A role for the spectrin superfamily member Syne-1 and
kinesin II in cytokinesis," Journal of Cell Science, vol.
The straight forward synthesis of DHPMs resulted in the discovery of many important agents such as calcium channel modulators, adrenergic receptor antagonists, and mitotic
kinesin inhibitors, in addition to anticancer, anti-inflammatory, antimicrobial, and antioxidant activities [9-13].