Glutamine can serve as an
anaplerotic mitochondrial fuel and seems to be important for tumor survival [95].
albicans downregulates glycolytic genes and upregulates glyoxylate cycle genes, which facilitate the assimilation of two carbon compounds with generation of
anaplerotic oxaloacetate to gluconeogenesis.
Significantly, inhibition of pyruvate oxidation stimulates
anaplerotic glutamine metabolism in human ESC [85], and glutamine-derived acetyl-CoA production in human cancer cells [86, 87], which are similarly increased in ESC [88].
Wallace, "
Anaplerotic roles of pyruvate carboxylase in mammalian tissues," Cellular and Molecular Life Sciences, vol.
That is, in addition to the classic [K.sub.ATP]-dependent mechanism, other mechanisms like
anaplerotic pathways maybe involved.
Kendrick, "Perspective: emerging evidence for signaling roles of mitochondrial
anaplerotic products in insulin secretion," The American Journal of Physiology--Endocrinology and Metabolism, vol.
OBJECTIVE: The beneficial effect of the natural compound propionyl-l-carnitine (PLC) on intermittent claudication in patients with peripheral arterial disease is attributed to its
anaplerotic function in ischemic tissues, but inadequate information is available concerning action on the vasculature.
2), which contributes to 50% of the
anaplerotic flux of glutamate into the tricarboxylic acid (TCA) cycle.
The major regulatory effect of N[H.sub.3] released by AMPD is its contribution to fumarate to the tricarboxylic acid cycle (TCA) (
anaplerotic function).
Experimental observation suggests that both
anaplerotic reactions and glyoxalate cycle play an important role for the production of tricarboxylic acid (TCA) cycle derived amino acids (aspartate which is a precursor of lysine and glutamate families) (Petersen, et al., 2001).