In human subjects, NK cells are controlled by killer immunoglobulin-like receptors (KIRs) that identify
allotypic determinants exhibited by diverse human leucocyte antigen (HLA) class I alleles.
MADS-box is an
allotypic gene family that is widely distributed in most species of the biological world.
(35) Human blood groups were regarded as classic
allotypic systems in which multiple alleles at a single locus encode a series of antigens.
Immunohistochemistry was performed on tissue sections using a monoclonal rat anti-mouse neutrophil (
allotypic marker clone 7/4) antibody (AbD Serotec, Raleigh, NC).
TRALI cases have been associated with plasma from female donors, which is thought to be related to the presence of
allotypic leukocyte antibodies in donors, stimulated by pregnancy and transfusions.
Description of
allotypic female.--Differing from holotype as follows.
There is no single correct amino acid sequence for immunoglobulin molecules because of
allotypic variations (20) and genetic differences in the variable region domains.
Yet, it is just such information that sets the foundation for understanding the function of allorecognition systems, how
allotypic diversity evolves, and the utility of allorecognition assays for deciphering the genetic structure of natural populations (Crozier 1987; Grosberg 1988; Grafen 1990).
Maokelao, "Low concentrations of Gm
allotypic subsets G3 mg and G1 mf in homozygotes and heterozygotes," The Journal of Immunology, vol.
Gras et al., "The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-[B.sup.*]41
allotypic family," Haematologica, vol.
If this is true, we also would assume that the HAMAs insensitive to MAK33 are directed against
allotypic or idiotypic epitopes (idiotopes) not related to the isotype of the Ig[G.sub.1[kappa]] antibodies.